Biocompatibility

Biocompatibility study for bioresorbable natural mineral fiber composites long-term effects:

Rabbit study with 26 weeks results; injection molded and continuous natural mineral fiber pin with standard negative control article (HD-PE).

4 weeks micro-CT:  cortex already closing.

13 weeks micro-CT:  bone growing around the implants

No difference in histology between the test articles and negative control.

Biocompatibility study for bioresorbable natural mineral fiber composites long term effects:

Dog study with 52 weeks results; continuous natural mineral fiber pin with reference pin without natural mineral fibers.

Natural mineral fiber composite at 6 weeks (A) and 12 weeks (B): Osseointegration and no fibrous capsule from 12 weeks ->

NB: new bone ; FM: fibrous tissue ; Os: Osseointegration

Significantly improved bone growth around natural mineral fiber composite.